DOES NSAID EXACERBATED RESPIRATORY DISEASE (N-ERD) ACCOMPANYING SEVERE ASTHMA AFFECT BIOLOGICAL TREATMENT RESPONSE? EFFICACY OF OMALIZUMAB AND MEPOLIZUMAB IN N-ERD

Does NSAID exacerbated respiratory disease (N-ERD) accompanying severe asthma affect biological treatment response? Efficacy of omalizumab and mepolizumab in N-ERD

Introduction: Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) accompanies severe asthma in about 15% of the patients and may adversely affect the prognosis.Omalizumab and mepolizumab are biologics used in patients with severe asthma.The objective of this study is to assess the respiratory improvements, after the

read more


HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages

HIV-1 infection of myeloid cells is associated with the induction of an IFN response.How HIV-1 manipulates and subverts the IFN response is of key interest for the design of therapeutics to improve immune function and mitigate immune dysregulation in people living with HIV.HIV-1 accessory genes function to improve viral fitness by altering host pat

read more